Cytoplasmic short linear motifs in ACE2 and integrin ? <sub>3</sub> link SARS-CoV-2 host cell receptors to mediators of endocytosis and autophagy
نویسندگان
چکیده
Peptide-binding assays suggest that SARS-CoV-2 receptors engage the endocytosis and autophagy machinery.
منابع مشابه
The pivotal link between ACE2 deficiency and SARS-CoV-2 infection
Angiotensin converting enzyme-2 (ACE2) receptors mediate the entry into the cell of three strains of coronavirus: SARS-CoV, NL63 and SARS-CoV-2. ACE2 receptors are ubiquitous and widely expressed in the heart, vessels, gut, lung (particularly in type2 pneumocytes and macrophages), kidney, testisand brain. ACE2 is mostly bound to cell membranes and only scarcely present in the circulation in a s...
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ژورنال
عنوان ژورنال: Science Signaling
سال: 2021
ISSN: ['1945-0877', '1937-9145']
DOI: https://doi.org/10.1126/scisignal.abf1117